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The anecdata seem to indicate that the mode of delivery, that is whether or not systemic or local, doesn't seem to matter that much

The second major mechanism is angiogenesis: the formation of new blood vessels

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All effects of GLP-1 are exerted by activation of the GLP-1 receptor, a seven transmembrane spanning Gprotein-coupled receptor (GPCR), leading to increased cAMP production and enhanced protein kinase A (PKA) activity

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